Health promoting lifestyle is a valuable source for reducing the incidence and impact of health problems and improving the quality of life. The purpose of this study is investigating the health-oriented lifestyle of women of reproductive ages. The statistical population of study is women of reproductive age living in Shiraz city. A sample of 392 person was selected thorough multiple stage cluster sampling. The study is based on Pender's health promotion model, although with some revisions. The result of Cronbach’s Alpha for the test of reliability for the lifestyle index is 0.87. The findings reveals that there is a significant relationship between the education of women, the study in areas of health, the use of communication media, social identity, social support, self-efficacy of health, self-reported general health, and awareness of health behavior with the dependent variable; health oriented life style. The study indicates that age of respondents, the marital status, employment status, household income and experience of some particular diseases do not have any significant relationship with the dependent variable. The results of regression models shows that four variables including self-efficacy of health, self-reported general health, the study in areas of health, and awareness of health behavior explain 51 percent of changes in variance of health oriented lifestyle. Among them, self-efficacy of health is the most influential one.