Recently, women’s participation has increased in the workplaces. Therefore it is a challenge for contemporary managers to help employees to balance their work and family responsibilities. This paper aims to identify factors affecting the work-family balance. Sample included 261 women employed at a number of universities in Tehran. Data is collected from the questionnaire. Correlation and multiple regression tests were used to analyze the data. Research variables are: family support, organizational support, work flexibility, and individual recourses. We suggested four hypotheses to exam the impact of family support, organizational support, work flexibility, and individual recourses on the work-family balance. The results show that family support and individual resources have positive impact on work-family balance, but organizational support and work flexibility have not significant impact on this variable. It is suggested to managers to encourage work-family supportive culture, and try to provide time and place flexibility of the work.