The aim of current study was assessing the relation of body image dissatisfaction and social anxiety with using of cosmetics in female college students.The method of this research was descriptive-analytical. The whole female students of Mohaghegh Ardabili University in second half of 2013 comprised statistical population of this study. One hundred and ten female students selected from this society by multistage randomly sampling. They were asked to respond questionnaires of social anxiety, body image dissatisfaction and researcher made questionnaire of using of cosmetics. Gathered data were analyzed by Pearson correlation and multivariate regression tests. The correlation results showed that the using ratio of cosmetics are related positively to body image dissatisfaction (r=0.44, P<0.001). Social anxiety (r=0.26, P<0.001) and its components as fear (r=0.28, P<0.004), physiological symptoms (r=0.22, P<0.02) and avoidance (r=0.21, P<0.03). The results of regression analysis also showed that 19% of variance of the using of cosmetics was explained by body image dissatisfaction and social anxiety disorder gender attitudes. Results of this study demonstrated that body image dissatisfaction and social anxiety disorder play role in the using of cosmetics.